Compatibility of various avian HA subtypes with the genome of human influenza A viruses
Identifieur interne : 001847 ( Main/Exploration ); précédent : 001846; suivant : 001848Compatibility of various avian HA subtypes with the genome of human influenza A viruses
Auteurs : Christoph Scholtissek [États-Unis] ; Jurgen Stech [États-Unis] ; Scott Krauss [États-Unis] ; Robert G. Webster [États-Unis]Source :
- International congress series [ 0531-5131 ] ; 2001.
English descriptors
- Teeft :
- Amantadine, Avian, Avian influenza, Avian strains, Avian virus, Elsevier science, Gene constellation, High yields, Hong kong, Human influenza, Human strain, Human virus, Human viruses, Influenza, Influenza pandemics, International congress series, Large plaque formers, Mdck cells, Other subtypes, Pandemic, Pandemic planning, Plaque, Reassortants, Reassortment, Scholtissek, Selection procedure, Singapore, Subtypes, Teal virus, Test system, Virus.
Abstract
Abstract: So far, with human influenza A viruses, only hemagglutinin (HA) subtypes 1, 2, or 3 were found. For pandemic planning, the question, whether other HA subtypes are compatible to create new human pandemic strains by reassortment, arises. Therefore, we crossed an amantadine-resistant variant of the human A/Singapore/57 (Sing) strain (H2N2) with various avian strains of different HA subtypes in the presence of amantadine and of anti-H2-antibodies. With A/Duck/Ukraine/63 (H3N8) and some other avian strains isolated recently in Hong Kong, large plaque-forming reassortants with the Sing-M-gene and the avian HA could be obtained in high yields, while with A/Chicken/Germany N/49 (Virus N) (H10N7) and some other avian strains, the yields were extremely low, and the remaining plaques were very small, and partly turbid and fuzzy. These observations may indicate that certain avian HA subtypes are not compatible to replace the HA-gene of the present human influenza A viruses to create a viable pandemic strain.
Url:
DOI: 10.1016/S0531-5131(01)00669-0
Affiliations:
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For pandemic planning, the question, whether other HA subtypes are compatible to create new human pandemic strains by reassortment, arises. Therefore, we crossed an amantadine-resistant variant of the human A/Singapore/57 (Sing) strain (H2N2) with various avian strains of different HA subtypes in the presence of amantadine and of anti-H2-antibodies. With A/Duck/Ukraine/63 (H3N8) and some other avian strains isolated recently in Hong Kong, large plaque-forming reassortants with the Sing-M-gene and the avian HA could be obtained in high yields, while with A/Chicken/Germany N/49 (Virus N) (H10N7) and some other avian strains, the yields were extremely low, and the remaining plaques were very small, and partly turbid and fuzzy. These observations may indicate that certain avian HA subtypes are not compatible to replace the HA-gene of the present human influenza A viruses to create a viable pandemic strain.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Tennessee</li></region></list><tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Scholtissek, Christoph" sort="Scholtissek, Christoph" uniqKey="Scholtissek C" first="Christoph" last="Scholtissek">Christoph Scholtissek</name></region><name sortKey="Krauss, Scott" sort="Krauss, Scott" uniqKey="Krauss S" first="Scott" last="Krauss">Scott Krauss</name><name sortKey="Stech, Jurgen" sort="Stech, Jurgen" uniqKey="Stech J" first="Jurgen" last="Stech">Jurgen Stech</name><name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G." last="Webster">Robert G. Webster</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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